7 free stealth attraction techniques summarized

Detailed description of the preparation and characterization of CM camouflaged polymer NPs and their applications in cancer treatment has been reported. A short section on CM and the development of CM coating technology has been provided. Herein, an overview is provided on the engineering of CM camouflaged polymer nanoparticles. This top-down CM coating process is facile and can provide some advantageous features over surface modification by synthetic polymers. One such modification is a biomimetic coating using cell membrane (CM), which can offer long circulation or targeting, or both. To achieve long circulation time, immune evasion, and targeted accumulation, conventional nanocarriers need modifications, e.g., PEGylation, peptide/aptamer attachment, etc. Although nanomedicines can address significant shortcomings of conventional therapy, biological barriers remain a challenge in their delivery and accumulation at diseased sites. Nanotechnology has revolutionized cancer drug delivery, and recent research continues to focus on the development of “one-size- fits-all,” i.e., “all-in-one” delivery nanovehicles. This study helps to rationalize design rules for stable and low-fouling polymersomes for future medical applications.

They further suggest that single copolymer presentation on polymersomes is outperformed by blends of varied copolymer lengths. In vitro macrophage association and in vivo blood circulation evaluation of polymersomes in zebrafish embryos corroborate these findings.

These observations support the experimentally demonstrated benefit of maximizing the length of PMOXA (degree of polymerization (DP) > 6) while keeping PDMS at a minimal length that still provides sufficient membrane stability (DP > 19).

The study relates in vitro antifouling performance of the polymersomes to atomistic molecular dynamics simulations of polymersome membrane hydration behavior. Herein, a systematic study is reported of the structural, dynamic and antifouling properties of polymersomes made of poly(2-methyl-2-oxazoline)-block-poly(dimethylsiloxane)-block-poly(2-methyl-2-oxazoline) (PMOXA-b-PDMS-b-PMOXA). Poly(2-oxazoline)s (POx) are valuable antifouling hydrophilic polymers that can replace the current gold-standard, poly(ethylene glycol) (PEG), yet investigations of POx functionality on nanoparticles are relatively sparse. However, the limited availability of systematic stability, protein fouling (protein corona formation), and blood circulation studies hampers their clinical translation.

Polymersomes are vesicular structures self-assembled from amphiphilic block copolymers and are considered an alternative to liposomes for applications in drug delivery, immunotherapy, biosensing, and as nanoreactors and artificial organelles.

7 free stealth attraction techniques summarized